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. 2015 Oct 13;5:15104. doi: 10.1038/srep15104

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Copyright © 2015, Macmillan Publishers Limited

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(A) JS-K-induced apoptosis in T24 and UM-UC-3 cells with or without NAC/GSSG. T24 and UM-UC-3 cells were cultured with 100 μM NAC or 5 μM GSSG for 24 h, and then treated with or without 5 μM JS-K. The cells were visualized by microscopy (100×). (B) Cell survival was detected by CCK-8 assay. (C) Cells were pretreated with 100 μM NAC or 5 μM GSSG for 24 h and subsequently treated with or without 5 μM JS-K for 6 h, ROS production was then measured. (D) Apoptosis was analyzed according to the distributions for the treatments in (A). Cytotoxicity (E) and caspase-3/7 activity (F) were determined according to the distributions for the treatments in (A). The data are presented as the mean ± SD for at least three independent experiments. Single asterisks (*) indicate a significant difference (P < 0.05), and double asterisks (**) indicate an extremely significant difference (P < 0.01).