Table 2. Association of variants in APOBEC genes with lung cancer risk.
Variant ID | Casesa | Controlsa | MAFb |
HWEc | Crude OR (95% CI) | Adjusted OR (95% CI)d | Pd | |
---|---|---|---|---|---|---|---|---|
Cases | Controls | |||||||
rs10911390 | 1053/144/3 | 1108/142/3 | 0.06 | 0.06 | 0.797 | 1.06 (0.84–1.35) | 1.12 (0.88–1.42) | 0.371 |
rs139293 | 957/206/20 | 912/297/15 | 0.10 | 0.13 | 0.108 | 0.75 (0.63–0.90) | 0.76 (0.63–0.91) | 0.002 |
rs139299 | 559/522/118 | 565/564/124 | 0.32 | 0.32 | 0.367 | 0.96 (0.85–1.09) | 0.96 (0.85–1.09) | 0.504 |
aMajor homozygote/heterozygote/minor homozygote.
bMAF: Minor allele frequency.
cHWE: Hardy-weinberg equilibrium in controls.
dAfter adjusting for age, gender and pack-year of smoking.