Table 3. Stratified analysis on the associations of rs139293 in APOBEC3H with lung cancer risk.
| Variables | Casesa | Controlsa | OR (95% CI)b | P-valueb | P-valuec |
|---|---|---|---|---|---|
| Age (years) | |||||
| <60 | 422/94/8 | 402/125/7 | 0.78 (0.60–1.03) | 0.080 | 0.723 |
| ≥60 | 535/112/12 | 510/172/8 | 0.73 (0.57–0.93) | 0.012 | |
| Sex | |||||
| Male | 676/143/16 | 624/196/10 | 0.79 (0.64–0.98) | 0.035 | 0.340 |
| Femal | 281/63/4 | 288/101/5 | 0.65 (0.47–0.92) | 0.014 | |
| Smoking states | |||||
| Never | 374/77/6 | 460/164/8 | 0.65 (0.49–0.86) | 0.003 | 0.122 |
| Ever | 583/129/14 | 452/133/7 | 0.87 (0.69–1.11) | 0.273 | |
| Smoking Levels | |||||
| ≤25 (Pack-years) | 177/42/5 | 214/65/2 | 1.02 (0.69–1.52) | 0.906 | 0.393 |
| >25 (Pack-years) | 406/87/9 | 238/68/5 | 0.82 (0.60–1.11) | 0.205 | |
| Histological types | |||||
| Squamous carcinoma | 352/63/5 | 912/297/15 | 0.65 (0.48–0.88) | 0.005 | 0.163 |
| Adenocarcinoma | 605/143/15 | 912/297/15 | 0.84 (0.68–1.02) | 0.082 | |
aMajor homozygote/heterozygote/minor homozygote.
bAfter adjusting for age, gender and pack-year of smoking where appropriate assuming an additive genetic model.
cP for heterogeneity.