Table 2. Annotated information and functionality of proteins with the highest degree.
| Gene ID | Degree | Feature | Uniprot ID | Protein functional description |
|---|---|---|---|---|
| ELAVL1 | 1307 | Bridge | Q15717 | Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. |
| IGF2BP3 | 713 | Bridge | O00425 | RNA-binding protein that act as a regulator of mRNA translation and stability. |
| SRSF1 | 629 | Q07955 | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. | |
| IGF2BP2 | 552 | Bridge | Q9Y6M1 | Binds to the 5′-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. |
| TARDBP | 540 | Bridge | Q13148 | DNA and RNA-binding protein which regulates transcription and splicing. |
| TIAL1 | 527 | Bridge | Q01085 | RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. |
| IGF2BP1 | 522 | Bridge | Q9NZI8 | RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. |
| FUS | 413 | P35637 | Binds both single-stranded and double-stranded DNA. | |
| PTBP1 | 327 | Bridge | P26599 | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. |
| TIA1 | 296 | P31483 | Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs). | |
| EWSR1 | 246 | Bridge | Q01844 | Might normally function as a transcriptional repressor. |
| FUS_mutant | 216 | P35637 | Binds both single-stranded and double-stranded DNA. | |
| AGO1-4 | 199 | Q9UL18; | Required for RNA-mediated gene silencing (RNAi). | |
| AGO2 | 180 | Q9UKV8 | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). | |
| TAF15 | 173 | Bridge | Q92804 | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. |
| MOV10 | 169 | Bridge | Q9HCE1 | Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). |
| PUM2 | 132 | Bridge | Q8TB72 | Sequence-specific RNA-binding protein that regulates translation and mRNA stability. |
| TNRC6A-C | 92 | Q8NDV7; | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). | |
| QKI | 85 | Bridge | Q96PU8 | RNA-binding protein that plays a central role in myelinization. |
The set of proteins with ‘bridge’ features indicate that its removal leads to a disconnected work, as explained in the text.