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. 2014 May 19;74(10):1907–1914. doi: 10.1136/annrheumdis-2013-205007

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Increased tetanic Ca²⁺ accompanied by muscle weakness in muscle fibres from collagen-induced arthritis (CIA) mice. (A) Typical examples (120 Hz stimulation frequency, 350 ms train duration) of [Ca²⁺]_i (left) and specific force (right) in control (—) and CIA (---) fibres. (B) [Ca²⁺]_i is significantly increased over a wide range of stimulation frequencies in fast-twitch FDB muscle fibres from CIA mice (•) compared with controls (○, Ctrl) (n=9–10). (C) Representative Commassie stained gels from fast-twitch muscles of CIA and control mice. (D) Mean expression of myosin and actin protein expression as measured from Commassie stained gels and normalised to total protein content (n=6). (E) Force per cross-sectional area was decreased in CIA muscle fibres (n=9–10). (F) Force–[Ca²⁺]_i curves, generated by plotting the mean force against the mean [Ca²⁺]_i at different frequencies. Data are mean±SEM; *p<0.05; **p<0.01; ***p<0.001 versus controls.