Table 3.
Inflammation signaling related gene expression in CD34+ cells of MPNs.
| Genes | Control | ET | PV | PMF | |||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| IL-6 signaling pathway related gene expression | |||||||||
| CEBPB | CCAAT/enhancer binding protein β | −0.3 | 0.48 | −0.5 | 0.63 | −0.3 | 0.49 | −0.1 | 0.54 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 2.46 | 0.87 | 3.11 | 1.04 | 3.74 | 0.95 | 2.35 | 1.38 |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 | 0.49 | 0.31 | 0.7 | 0.15 | 1.06 | 0.26 | 0.19 | 0.52 |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 1.66 | 0.29 | 2.02 | 0.27 | 2.11 | 0.34 | 1.95 | 0.38 |
| SHC1 | Src homology 2 domain cont transforming protein 1 | −0.7 | 0 | −0.3 | 0.54 | 0.27 | 0.04 | −1.1 | 0 |
| CSNK2A1 | Casein kinase 2, α 1 polypeptide | 0.23 | 0.06 | 0.23 | 0.05 | 0.35 | 0.51 | 0.48 | 0.52 |
|
| |||||||||
| NF-κB signaling pathway related gene expression | |||||||||
| TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | 0.58 | 0.72 | 1.26 | 0.86 | 1.54 | 0.42 | 1.64 | 0.40 |
| NFKBIA | Nuclear factor of kappa light polypept gene enhancer in B-cells inhibitor, α | 4.24 | 0.82 | 3.70 | 1.02 | 3.57 | 0.91 | 2.82 | 1.06 |
| TRADD | TNFRSF1A-associat via death domain | 1.30 | 0.42 | 1.67 | 0.22 | 1.79 | 0.31 | 1.38 | 0.32 |
| NFKB1 | Nuclear factor of kappa light polypept gene enhancer in B-cells 1 | 0.69 | 0.17 | 0.28 | 1.13 | 1.17 | 0.24 | 1.34 | 1.16 |
|
| |||||||||
| TGF-beta signaling pathway related gene expression | |||||||||
| CDKN2B | Cyclin-dependent kinase inhibitor 2B | 0.64 | 1.05 | −0.1 | 1.15 | −0.7 | 1.11 | −1.2 | 1.14 |
| ID3 | Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | −2.1 | 0.48 | −2.4 | 0.65 | −3.1 | 0.14 | −3.1 | 0.37 |
| TFDP1 | Transcription factor Dp-1 | −0.1 | 0.49 | 0.11 | 0.4 | 0.61 | 0.4 | 0.96 | 0.69 |
| BMPR2 | Bone morphogenetic prot rec type II | 1.99 | 0 | 1.02 | 0.89 | 2.01 | 0.16 | ||
| TGFBR1 | Transforming growth factor, β recep 1 | 0.59 | 0.35 | 1.04 | 0.5 | 0.66 | 0.14 | ||
| TGFBR2 | Transforming growth factor, β recep II | 1.67 | 0.18 | 1.55 | 0.29 | 1.61 | 0 | ||
|
| |||||||||
| IL-10 signaling pathway related gene expression | |||||||||
| BLVRA | Biliverdin reductase A | 0.70 | 0.59 | 1.13 | 0.45 | 1.50 | 0.40 | 1.31 | 0.29 |
| IL10RB | Interleukin 10 receptor | 0.96 | 0.31 | 1.30 | 0.70 | 1.15 | 0.73 | 0.83 | 0.75 |
| HMOX1 | Heme oxygenase (decycling) 1 | 1.30 | 0.44 | 2.41 | 0.44 | 2.32 | 0.59 | ||
Bolded genes represent significantly changed expression versus controls (p < 0.05).