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. Author manuscript; available in PMC: 2015 Oct 13.
Published in final edited form as: Nat Rev Cancer. 2010 Jul;10(7):470–480. doi: 10.1038/nrc2877

Figure 3. Human in mouse transplantation models.

Figure 3

Pluripotent human stem cells are grown ex vivo on feeder cells and transduced with the oncogenic elements of interest. Without long culture times, the cells are injected into orthotopic sites on the mice with or without humanized stromal cells. Here, the tumour types of interest will develop from human cells within the context of the relevant mouse or human normal stroma.