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PROX1 transcriptionally regulates the expression of NOTCH1, E2F1, GATA3, and WISP3. NOTCH1 (A) and E2F1 (B) were downregulated in SCC9-PROX1 cell clones compared with control cells as well as GATA3 (C) and WISP3 (D) that were upregulated. PROX1 = prospero homeobox 1.
