Table 3.
Comparison of the metabolic parameters with MTTP genotypes
| Genotype | BMI (kg/m2) | P | TG (mg/dl) | P | HOMA-IR | P | Adipo-IR | P |
|---|---|---|---|---|---|---|---|---|
| (promoter) G-493T | ||||||||
| GG+GT (n = 1155) | 24.5 ± 3.3 | 0.527 | 138.3 ± 123.9 | 0.039* | 1.09 ± 2.29 | 0.572 | 2.46 ± 3.84 | 0.014* |
| TT (n = 29) | 24.7 ± 2.5 | 117.1 ± 49.7 | 0.83 ± 0.72 | 1.61 ± 1.32 | ||||
| Glu98Asp (E98D) | ||||||||
| GG+GC (n = 1127) | 24.5 ± 3.3 | 0.050* | 137.0 ± 120.9 | 0.001* | 1.09 ± 2.31 | 0.044* | 2.48 ± 3.87 | 0.436 |
| CC (n = 25) | 22.6 ± 2.3 | 101.3 ± 43.2 | 0.61 ± 1.02 | 1.78 ± 2.98 | ||||
| Ile128Thr (I128T) | ||||||||
| TT+TC (n = 1148) | 24.5 ± 3.3 | 0.640 | 138.1 ± 123.6 | 0.040* | 1.08 ± 2.29 | 0.140 | 2.46 ± 3.86 | 0.017* |
| CC (n = 26) | 24.8 ± 2.6 | 114.9 ± 51.9 | 0.833 ± 0.75 | 1.57 ± 1.38 | ||||
| Asn166Ser (N166S) | ||||||||
| AA+AG (n = 1145) | 24.5 ± 3.3 | 0.006* | 138.6 ± 123.9 | 0.001* | 1.05 ± 1.92 | 0.301 | 2.43 ± 2.75 | 0.442 |
| GG (n = 24) | 22.7 ± 2.3 | 102.8 ± 44.3 | 0.62 ± 1.04 | 1.77 ± 2.98 | ||||
| Gln297His (Q297H) | ||||||||
| GG+GC (n = 984) | 24.5 ± 3.4 | 0.913 | 136.9 ± 124.1 | 0.656 | 1.09 ± 2.43 | 0.451 | 0.57 ± 0.23 | 0.337 |
| CC (n = 193) | 24.5 ± 2.9 | 141.2 ± 116.2 | 0.92 ± 0.98 | 0.58 ± 0.25 | ||||
Data are shown as mean ± SD
Independent t test was used for statistical analysis of body mass index (BMI) and insulin resistance (HOMA-IR and Adipo-IR)
Mann–Whitney U test was used to analyze triglyceride (TG). (* P < 0.05 indicates significant)