Table 2.
Virulence factors distribution according to phylogenetic group
| Phylogenetic group |
||||||
|---|---|---|---|---|---|---|
| All isolates | A | B1 | B2 | D | ||
| Virulence-related gene | n = 120 | n = 36 | n = 13 | n = 50 | n = 21 | P |
| Adhesins | ||||||
| papC | 58 (48.3) | 10 (27.8) | 4 (30.8) | 32 (64) | 12 (57.1) | 0.004 |
| papG allele I | 0 | 0 | 0 | 0 | 0 | — |
| papG allele II | 36(30) | 4 (11.1) | 2 (15.4) | 23 (46) | 7 (33.3) | 0.003 |
| papG allele III | 12 (10) | 2 (5.6) | 0 | 10 (20) | 0 | 0.018 |
| afaB/C | 3 (2.5) | 0 | 0 | 2 (4) | 1 (4.8) | — |
| fimH | 115(95.8) | 32 (88.9) | 13 (100) | 50 (100) | 21 (95.2) | — |
| iha | 42 (35) | 7 (19.4) | 4 (30.8 | 19 (38) | 12 (57.1) | — |
| sfa/focDE | 24(20) | 2 (5,6) | 2 (15,4) | 20 (40) | 0 | <0.0001 |
| Toxins | ||||||
| cdtB | 7 (5.8) | 0 | 0 | 5 (10) | 2 (9.5) | — |
| cnf1 | 17 (14.2) | 0 | 0 | 17 (34) | 0 | <0.0001 |
| hlyA | 28 (23.3) | 4 (11.1) | 2 (15.4) | 20 (40) | 2 (9.5) | 0.004 |
| Sat | 32 (26.7) | 2 (5.6) | 4 (30.8) | 16 (32) | 10 (47.6) | 0.003 |
| Usp | 69 (57.5) | 5 (13.9) | 6 (46.2) | 50 (100) | 8 (38.1) | <0.0001 |
| Protectins | ||||||
| kpsMTII | 66 (55) | 8 (22.2) | 6 (4.2) | 38 (76) | 14 (66.7) | <0.0001 |
| ompT | 90 (75) | 17 (47.2) | 8 (61.5) | 50 (100) | 15 (71.4) | <0.0001 |
| Iron-uptake | ||||||
| iroN | 61 (50.8) | 18 (80) | 10 (76.9) | 31 (62) | 2 (9.5) | <0.0001 |
| fyuA | 91 (75.8) | 19 (52.8) | 8(61.5) | 50 (100) | 14 (66.7) | <0.0001 |
| iutA | 83 (69.2) | 23 (63.9) | 10 (76.9) | 36 (72) | 14 (66.7) | — |
| iucD | 77 (64.2) | 21 (58.3) | 10 (76.9) | 33 (66) | 13 (61.9) | — |
| ireA | 23 (19.2) | 3 (8.3) | 4 (30.8) | 13 (26) | 3 (14.3) | — |
| Betalactamases | ||||||
| TEM | 67 (55.8) | 25 (69.4) | 7 (53.4) | 26 (52) | 9 (42.9) | — |
| CTX-M | 5 (4.2) | 1 (2.7) | 1 (7.7) | 3 (6) | 0 | — |
| VIM | 1 (0.8) | 0 | 0 | 1 (2) | 0 | — |
| Miscellaneous | ||||||
| malX | 68 (56.7) | 6 (16.7) | 6 (46.2) | 49 (98) | 7 (33.3) | <0.0001 |
| svg | 12 (10) | 1 (2.8) | 1 (7.7) | 9 (18) | 1 (4.8) | — |
| ibeA | 16 (13.3) | 1 (2.8) | 0 | 11 (22) | 4 (19) | — |
| tratT | 76 (63.3) | 20 (55.6) | 10 (76.9) | 36 (72) | 10 (47.6) | — |
| cvaC | 25 (20.8) | 13 (36.1) | 2 (15.4) | 10 (20) | 0 | — |
| Median Virulence score (IQR) | 9 (6–13) | 6.50 (4–8.75) | 8 (4–12) | 13 (10–15) | 9 (6–10) | |
Note: Data are displayed as number (%) of isolates. papC, P fimbrial; papG allele I, II y III, P fimbrial adhesin molecule, with variants I, II, and III; afaB/C, afimbrial adhesin; fimH, type 1 fimbrial adhesion, iha, bifunctional enterobactin receptor/adhesin; sfa/foc, S and F1C fimbriae; cdtB, cytolethal distending toxin; cnf, cytotoxic necrotizing factor; hlyA, hemolysin; sat, secreted autotransporter toxin; usp, uropathogenic specific protein; kpsMTII, group II capsule synthesis; iroN, putative catecholate siderophore receptor; fyuA, yersiniabactin receptor; iutA, aerobactin receptor; iucD, aerobactin biosynthesis; TEM and CTX-M betalactamases; VIM metallobetalactamase; malX, marker for pathogenicity-associated island from strain CFT073; svg, specific for virulence subgroup; ibeA, invasion of brain endothelium A; traT, serum-resistance associated outer membrane protein; cvaC, colicin V receptor. -, not significant.