Fig. 2.

Schematic overview of the analyses in this study. (Upper) Triangles denote somatic missense mutations in individual samples; bars labeled s1–s5 represent PDB structures covering different parts of the protein sequence; the representative structures, s1 and s5, selected with our heuristic (Materials and Methods) are highlighted in black. (Lower) Mutated residues are shown as pins (red: recurrent, pink: nonrecurrent mutation).