Table 2.

Summary of steady-state kinetic parameters fit from titrations in which the concentration of the H3K4me3 amino acids 1–21 peptide was held at 400 μM and the acetyl-CoA concentration was varied

HAT module	Substrate	kcat, s−1	Km, μM	kcat/Km, μM−1⋅s−1
Wild type	Ac-CoA	1.7 ± 0.1	3.4 ± 0.7	0.50 ± 0.1
ΔTudor	Ac-CoA	1.8 ± 0.1	2.8 ± 0.3	0.64 ± 0.08