Figure 3.
Concentration of cytokine/chemokines in A549 lung epithelial cell cultures over time following infection with RSV clinical isolates. Cytokine/chemokines (A) IL-1α, (B) IL-6, (C) IL-8 (p=0.028) (D) RANTES (p=0.019) were measured. MOI was held at 0.10. Inpt=RSV isolated from infants with severe RSV disease requiring hospitalization. Outpt=RSV isolated from infants with mild RSV disease. 48 hr, 60 hr and 72 hr represent time from point of culture inoculation. Error bars represent SEM of pooled viral isolate cytokine/chemokine concentrations for Inpt and Outpt over all time points from culture inoculation.