Table 1.
Available transgenic zebrafish models of cancer. Adapted from [3].
| Cancer | Oncogene | Tumor suppressor | Use in cancer biology | PMID |
|---|---|---|---|---|
| Melanoma | mitfa-BRAFV600E | p53−/− | Genetic and chemical modifier screens | 15694309 [14] |
| mitfa:EGFP:NRASQ61K | p53−/− | 19954345 [33] | ||
| kita-Gal4 x UAS-HRAS | 21170325 [45] | |||
| Pancreatic | ptf1a-KRASG12V-GFP | Genetic modifier screens | 18549880 [46] | |
| ptf1a:Gal4-VP16 x UAS-KRASG12V-GFP | 21951538 [47] | |||
| T-cell lymphoma/leukemia | rag2-myc | Cancer modeling, in vivo imaging | 12574629 [13]; 15827121 [48] | |
| rag2-s lox-dsRED2-lox-EGFP-mMyc x hsp70-cre | Inducible cancer models | 17593023 [49] | ||
| rag2-NOTCH1 | Notch1 interaction with bcl2 | 17252014 [50]; 22538478 [51] | ||
| rag2-myc x rag2-bcl2 | Mechanisms of leukemia dissemination | 20951945 [52] | ||
| B-cell leukemia | Xenopus EF1a or zebrafish B actin – TEL-AML1 (ETV6-RUNX1) | Initiating events in B-cell leukema | 17015828 [53] | |
| Numerous | b-actin-lox-GFP-lox-KRASG12D x hsp70-cre | Inducible cancer models | 17517602 [54] | |
| krt4:Gal4VP16;14 x UAS:smoa1-EGFP x UAS:myrhAKT1 | Cooperation of hedgehog and Akt pathways | 19555497 [55] | ||
| Rhabdomyosarcoma | rag2-KRASG12D | Identification of tumor initiating cell populations | 17510286 [15] | |
| Neuroblastoma | dβh:EGFP-MYCN | Cooperation of MYCN and ALK | 22439933 [56] | |
| dβh:EGFP and dβh:ALKF1174L | Cooperation of MYCN and ALK | 22439933 [56] | ||
| AML | spi1(pu.1)-MYST3/NCOA2-EGFP | First model of AML in zebrafish | 18729850 [57] | |
| MPNST | p53−/− | Conservation of tumor suppressor pathways in fish Major tumor type found in p53-deficient zebrafish |
15630097 [9] | |
| Lipoma | krt4Hsa.myrAkt1 | Platform for the study of drugs to treat lipoma and/or obesity | 22623957 [58] | |
| Ewing’s sarcoma | hsp70 or beta actin-EWS/FLI1 | p53−/− | Conserved function of EWS-FLI1 fusion protein from human to fish | 21979944 [59] |
| Liver | fabp10:LexPR; LexA:EGFP x cryB:mCherry; LexA:EGFP-krasV12 | Inducible KRAS hepatocellular cancer model | 21903676 [60] | |
| fabp10:TA; TRE:xmrk; krt4:GFP | Inducible EGFR-homolog hepatocellular cancer model | 21888874 [61] | ||
| Pancreatic neuroendocrine | zmyod–MYCN | Pancreatic neuroendocrine model as a platform for downstream MYCN targets | 15492244 [62] | |
| Myeloproliferative neoplams | sp1(pu.1)-NUP98-HOXA9 | NUP98-HOXA9-induced oncogenesis from defects in haematopoiesis and aberrant DNA damage response | 21810091 [63] | |
| Corticotroph adenoma/neoplasm | POMC-PTTG (securin) | Identification of CDK inhibitors as possible treatment of corticotrph tumors | 21536883 [64] | |
| Testicular germ cell tumor | fugu flck-SV40 large T | Platform for modifier screens of testicular tumors | 21158563 [65] |