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. Author manuscript; available in PMC: 2015 Oct 13.
Published in final edited form as: Adv Virus Res. 2013;87:1–35. doi: 10.1016/B978-0-12-407698-3.00001-6

Figure 9. Model of reovirus hematogenous spread from the intestine.

Figure 9

(1) Following peroral inoculation, reovirus infects intestinal epithelial cells (2) and is taken up by lymphoid cells in the Peyer patch. (3) Infected dendritic cells or lymphocytes carry reovirus from the Peyer patch through the lymphatics and finally to the blood. (4) Phagocytic cells that extend processes into the lumen of the intestine also might be infected for subsequent transport of virus through the lymphatics. (5) Reovirus may enter directly into the blood by passing between endothelial cells or via release into the bloodstream from infected cells.