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The wide-open state ATP of profilin:actin is more solvent exposed. (a) Wide-open state profilin:actin solvent accessible surface (SAS). (b) SAS of partially-open state profilin:actin. (c) SAS of nonexchanging-closed state actin. Zoomed-in crosseye stereo pairs (right panels) shows the solvent accessibility of ATP looking down the nucleotide cleft. For the zoomed views, the molecule was rotated 90° about the z-axis.
