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. Author manuscript; available in PMC: 2015 Oct 13.
Published in final edited form as: J Mol Biol. 2012 Feb 22;418(0):103–116. doi: 10.1016/j.jmb.2012.02.012

Figure 7.

Figure 7

Profilin prevents dual conformations for Trp-356 in the wide-open state. (a) 2FO-FC density (1.5 σ) for wide-open state Trp-356. (b) Trp-356 single conformation in the wide-open state (blue) and dual conformations in the nonexchanging-closed state (green). (c) In the wide-open state His-119 on profilin blocks the concerted motions of Met-355, Phe-352 and therefore, Trp-356 is extended to the surface. (d) Corresponding view for the nonexchaning-closed state showing the dual conformation for Met-355, Phe-352 and Trp-365 that are not blocked by gelsolin.