Shows variation of HCV genotypes among Egyptian and Saudi Arabian patients identified by RT-PCR. Our study showed that HCV genotype 4 was found to be the predominant genotype among Egyptian and Saudi Arabian chronic patients. Of these samples, 17/20 (85%), 2/20 (10%), and 1/20 (5%) of Egyptian patients were genotypes 4, mixed 4.1b, and 1, respectively. Of the Saudi Arabian patients, 12/20 (60%), 2/20 (25%), 2/20 (10%), and 1/20 (5%) were genotypes 4, 1, mixed 4.1b, and 2, respectively.