Table 2.
Pooled ORs and 95% CIs for the association between p53 genetic polymorphism and AML susceptibility.
| Overall and subgroups | N | Pro vs. Arg | ProPro vs. ArgArg | ArgPro vs. ArgArg | (ProPro + ArgPro) vs. ArgArg | ProPro vs. (ArgPro + ArgArg) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | I2 (%) | OR (95%CI) | I2 (%) | OR (95%CI) | I2 (%) | OR (95%CI) | I2 (%) | OR (95%CI) | I2 (%) | ||
| Overall | 6 | 0.94 (0.81–1.10) | 30 | 0.93 (0.71–1.22) | 21.55 | 0.79 (0.55–1.13) | 69.2 | 0.84 (0.62–1.13) | 60 | 1.06 (0.83–1.35) | 23 |
| Source of controls | |||||||||||
| PB | 4 | 0.88 (0.77–1.02) | 6.37 | 0.80 (0.58–1.09) | 0 | 0.74 (0.51–1.08) | 67.3 | 0.78 (0.58–1.04) | 51.36 | 0.97 (0.69–1.36) | 30.46 |
| HB | 2 | 1.17 (0.90–1.54) | 0 | 1.53 (0.87–2.69) | 0 | 0.87 (0.27–2.78) | 80.87 | 1.00 (0.40–2.52) | 72.94 | 1.34 (0.82–2.17) | 0 |
| Ethnicity | |||||||||||
| Asian | 4 | 0.91 (0.73–1.14) | 53.73 | 0.89 (0.58–1.38) | 48.92 | 0.79 (0.49–1.27) | 74.75 | 0.82 (0.54–1.24) | 69.29 | 1.02 (0.72–1.44) | 36.67 |
| Caucasian | 2 | 1.02 (0.81–1.28) | 0 | 1.07 (0.59–1.94) | 0 | 0.77 (0.34–1.72) | 68.05 | 0.89 (0.54–1.49) | 39.59 | 1.29 (0.59–2.78) | 34.33 |
HB – hospital based; PB – population based; OR – odds ratio; CI – confidence interval; I2 – test for heterogeneity.