Table 3.
Genetic determinants of vitamin D status in healthy adult females
| SNP | Genotype | Serum 25(OH) D <50 nmol/L N (%) | aOR (95 % CI) | P value |
|---|---|---|---|---|
| VDR, rs731236a | AA | 53/65 (81 %) | Ref | - |
| AG/GG | 72/94 (77 %) | 1.57 (0.65–3.78) | 0.31 | |
| VDR, rs1544410b | CC | 36/45 (80 %) | Ref | - |
| CT/TT | 92/118 (80 %) | 1.72 (0.65–4.54) | 0.26 | |
| VDR, rs2228570c | GG | 85/107 (79 %) | Ref | - |
| GA/AA | 43/57 (75 %) | 2.07 (0.84–5.09) | 0.11 | |
| CYP2R1, rs10500804d | GG | 33/44 (75 %) | Ref | - |
| GT/ TT | 90/115 (78 %) | 0.76 (0.30–1.93) | 0.57 | |
| CYP2R1, rs2060793e | GG | 60/81 (74 %) | Ref | - |
| GA /AA | 66/79 (83 %) | 0.57 (0.21–1.23) | 0.13 | |
| Cyp2R1, rs10766197f | AA | 28/38 (74 %) | Ref | - |
| AG/ GG | 98/124 (79 %) | 0.83 (0.32–2.15) | 0.70 | |
| DBP, rs7041g | AA | 29/36 (80 %) | Ref | - |
| AC/CC | 96/124 (77 %) | 1.16 (0.41–3.24) | 0.77 | |
| DBP, rs4588h | GG | 63/76 (83 %) | Ref | - |
| GT /TT | 65/88 (74 %) | 2.21 (0.89–5.00) | 0.09 |
aOR odd ratios adjusted for education, sun exposure time, month of recruitment and multivitamin supplementation; SNP, single nucleotide polymorphism, VDR, Vitamin D receptor; DBP, Vitamin D binding protein; CYP2R1, Vitamin D 25-hydroxylase
a n = 159
b n = 163
c n = 164
d n = 159
e n = 160
f n = 162
g n = 160
h n = 164