Table 3.

Cerium concentration in different tissues at 7 days after gavage administration of uncoated or silica-coated CeO₂ NPs

	CeO2	Silica-coated CeO2
	ng/g ± SE	ng/g ± SE
Lungs	0.27 ± 0.16	0.07 ± 0.03
Liver	0.11 ± 0.04	0.07 ± 0.03
Bone	0.55 ± 0.31	0.06 ± 0.06
Cecum	0.22 ± 0.08	0.18 ± 0.13
Large intestine	0.76 ± 0.72	0.20 ± 0.15
Bone marrow	0.00 ± 0.00	0.25 ± 0.25
Spleen	0.06 ± 0.06	0.15 ± 0.15
Stomach	0.31 ± 0.18	2.64 ± 1.84
Kidneys	0.13 ± 0.13	0.09 ± 0.04
Small intestine	0.12 ± 0.05	0.39 ± 0.27
Heart	0.34 ± 0.21	0.35 ± 0.21
Testes	0.04 ± 0.04	0.09 ± 0.04
Skeletal muscle	0.06 ± 0.05	0.01 ± 0.01
Brain	0.05 ± 0.05	0.00 ± 0.00
Skin	0.04 ± 0.04	0.04 ± 0.02
Plasma	0.04 ± 0.04	0.03 ± 0.03
RBC	0.00 ± 0.00	0.03 ± 0.03

Data are mean ± SE ng/g cerium concentration, n = 5/group

Ce concentration was estimated (ng/μCi_NPs x μCi/g_tissue)

No significant difference was observed between the two group