Table 4.

Cerium concentration in different tissues at 2 hours after intravenous injection of uncoated or silica-coated CeO₂ NPs

	CeO2	Silica-coated CeO2
	ng/g ± SE	ng/g ± SE
Lungs	14.37 ± 1.79	54.62 ± 4.93 *
Liver	1951.79 ± 44.49	1663.68 ± 67.67 *
Bone	3.38 ± 0.44	6.42 ± 1.14 *
Cecum	0.62 ± 0.43	0.21 ± 0.03
Large intestine	0.36 ± 0.09	0.28 ± 0.05
Bone marrow	1.73 ± 0.34	4.67 ± 0.70 *
Spleen	1680.71 ± 357.91	1204.38 ± 171.76
Stomach	3.77 ± 1.67	4.77 ± 2.38
Kidneys	3.09 ± 1.44	5.27 ± 0.29
Small intestine	1.37 ± 0.20	1.12 ± 0.14
Heart	0.77 ± 0.15	1.41 ± 0.26
Testes	0.09 ± 0.02	0.19 ± 0.01 *
Skeletal muscle	0.16 ± 0.05	0.23 ± 0.01
Brain	0.04 ± 0.00	0.11 ± 0.02 *
Skin	0.20 ± 0.03	0.68 ± 0.04 *
Plasma	0.14 ± 0.03	0.14 ± 0.03
RBC	2.66 ± 0.51	2.07 ± 0.23

Data are mean ± SE ng/g cerium concentration, n = 5/group

Ce concentration was estimated (ng/μCi_NPs x μCi/g_tissue)

*P < 0.05, CeO₂ vs. silica-coated CeO₂