Table 5.

Cerium concentration in different tissues at 2 days after intravenous injection of uncoated or silica-coated CeO₂ NPs

	CeO2	Silica-coated CeO2
	ng/g ± SE	ng/g ± SE
Lungs	5.65 ±1.53	23.15 ± 2.83 *
Liver	1904.43 ± 93.22	1652.57 ± 38.07 *
Bone	2.72 ± 0.64	10.95 ± 1.61 *
Cecum	0.15 ± 0.02	0.95 ± 0.26 *
Large intestine	0.21 ± 0.03	1.07 ± 0.29 *
Bone marrow	1.42 ± 0.28	6.64 ± 1.23 *
Spleen	1096.02 ± 333.49	1822.33 ± 181.83
Stomach	2.01 ± 0.89	3.29 ± 1.25
Kidneys	1.32 ± 0.18	6.32 ± 0.58 *
Small intestine	1.47 ± 0.14	0.63 ± 0.12 *
Heart	0.75 ± 0.26	1.05 ± 0.12
Testes	0.02 ± 0.01	0.20 ± 0.02 *
Skeletal muscle	0.05 ± 0.01	0.18 ± 0.02 *
Brain	0.02 ± 0.01	0.08 ± 0.02 *
Skin	0.19 ± 0.03	0.52 ± 0.08 *
Plasma	0.02 ± 0.01	0.09 ± 0.02 *
RBC	0.30 ± 0.69	0.69 ± 0.03 *

Data are mean ± SE ng/g cerium concentration, n = 5/group

Ce concentration was estimated (ng/μCi_NPs x μCi/g_tissue)

*P < 0.05, CeO₂ vs. silica-coated CeO₂