Table 4.

Association between the selected SNPs in pre-microRNAs and tumor stage

Genetic model	Genotype	Invasive	Superficial	Logistic regressiona
		n = 84	n = 75	OR (95 % CI)	P
mir-196a2 rs11614913 C/T
Codominant	T/T	27 (32.1 %)	25 (33.3 %)	1	0.68
	C/T	33 (39.3 %)	33 (44 %)	0.63 (0.21–1.86)
	C/C	24 (28.6 %)	17 (22.7 %)	1.45 (0.43–5.00)
Dominant	T/T	27 (32.1 %)	25 (33.3 %)	1	0.39
	C/T-C/C	57 (67.9 %)	50 (66.7 %)	0.65 (0.24–1.74)
Recessive	T/T-C/T	60 (71.4 %)	58 (77.3 %)	1	0.83
	C/C	24 (28.6 %)	17 (22.7 %)	1.12 (0.39–3.23)
Overdominant	T/T-C/C	51 (60.7 %)	42 (56 %)	1	0.52
	C/T	33 (39.3 %)	33 (44 %)	0.74 (0.28–1.91)
Log-additive	—	—	—	0.82 (0.45–1.49)	0.51
mir-499 rs3746444 G/A
Codominant	A/A	52 (61.9 %)	55 (73.3 %)	1	0.25
	G/A	28 (33.3 %)	17 (22.7 %)	1.96 (0.67–5.88)
	G/G	4 (4.8 %)	3 (4 %)	3.70 (0.50–25.00)
Dominant	A/A	52 (61.9 %)	55 (73.3 %)	1	0.12
	G/A-G/G	32 (38.1 %)	20 (26.7 %)	2.22 (0.81–5.88)
Recessive	A/A-A/A	80 (95.2 %)	72 (96 %)	1	0.26
	G/G	4 (4.8 %)	3 (4 %)	3.13 (0.44–25.00)
Overdominant	A/A-G/G	56 (66.7 %)	58 (77.3 %)	1	0.27
	G/A	28 (33.3 %)	17 (22.7 %)	1.82 (0.63–0.92)
Log-additive	—	—	—	0.51 (0.23–1.13)	0.094
mir146a rs2910164 C/G
Codominant	C/C	30 (35.7 %)	30 (40 %)	1	0.034
	C/G	45 (53.6 %)	28 (37.3 %)	1.41 (0.50–4.00)
	G/G	9 (10.7 %)	17 (22.7 %)	0.24 (0.06–1.01)
Dominant	C/C	30 (35.7 %)	30 (40 %)	1	0.84
	C/G-G/G	54 (64.3 %)	45 (60 %)	1.11 (0.42–2.89)
Recessive	C/C-C/G	75 (89.3 %)	58 (77.3 %)	1	0.012
	G/G	9 (10.7 %)	17 (22.7 %)	0.20 (0.05–0.72)
Overdominant	C/C-G/G	39 (46.4 %)	47 (62.7 %)	1	0.097
	C/G	45 (53.6 %)	28 (37.3 %)	2.17 (0.86–5.56)
Log-additive	—	—	—	1.66 (0.84–3.31)	0.14

^aAdjusted by gender, age, smoking status, tumor stage, recurrence, and metastasis. Italicized values indicated a significant difference at the 5 % level

n number of individuals