Table 5.

Association between the selected SNPs in pre-microRNAs and metastasis

Genetic model	Genotype	Metastasis	No metastasis	Logistic regressiona
		n = 132	n = 27	OR (95 % CI)	P
mir-196a2 rs11614913 C/T
Codominant	T/T	40 (30.3 %)	12 (44.4 %)	1	0.28
	C/T	56 (42.4 %)	10 (37 %)	1.33 (0.47–3.85)
	C/C	36 (27.3 %)	5 (18.5 %)	2.63 (0.77–9.09)
Dominant	T/T	40 (30.3 %)	12 (44.4 %)	1	0.23
	C/T-C/C	92 (69.7 %)	15 (55.6 %)	1.75 (0.70–4.35)
Recessive	T/T-C/T	96 (72.7 %)	22 (81.5 %)	1	0.13
	C/C	36 (27.3 %)	5 (18.5 %)	2.33 (0.74–7.14)
Overdominant	T/T-C/C	76 (57.6 %)	17 (63 %)	1	0.87
	C/T	56 (42.4 %)	10 (37 %)	1.08 (0.42–2.81)
Log-additive	—	—	—	0.63 (0.35–1.14)	0.12
mir-499 rs3746444 G/A
Codominant	A/A	89 (67.4 %)	18 (66.7 %)	1	0.37
	G/A	38 (28.8 %)	7 (25.9 %)	1.72 (0.60–5.00)
	G/G	5 (3.8 %)	2 (7.4 %)	0.46 (0.06–3.45)
Dominant	A/A	89 (67.4 %)	18 (66.7 %)	1	0.45
	G/A-G/G	43 (32.6 %)	9 (33.3 %)	0.69 (0.26–1.86)
Recessive	A/A-G/A	127 (96.2 %)	25 (92.6 %)	1	0.35
	G/G	5 (3.8 %)	2 (7.4 %)	0.37 (0.05–2.70)
Overdominant	A/A-G/G	94 (71.2 %)	20 (74.1 %)	1	0.23
	G/A	38 (28.8 %)	7 (25.9 %)	1.85 (0.65–5.26)
Log-additive	—	—	—	0.89 (0.39–2.04)	0.78
mir146a rs2910164 C/G
Codominant	C/C	46 (34.9 %)	14 (51.9 %)	1	0.081
	C/G	62 (47 %)	11 (40.7 %)	2.27 (0.83–6.25)
	G/G	24 (18.2 %)	2 (7.4 %)	5.00 (0.86–25.00)
Dominant	C/G	46 (34.9 %)	14 (51.9 %)	1	0.04
	C/G-G/G	86 (65.2 %)	13 (48.1 %)	2.63 (1.03–6.67)
Recessive	C/G-C/G	108 (81.8 %)	25 (92.6 %)	1	0.12
	G/G	24 (18.2 %)	2 (7.4 %)	3.33 (0.62–16.67)
Overdominant	C/C-G/G	70 (53 %)	16 (59.3 %)	1	0.31
	C/G	62 (47 %)	11 (40.7 %)	1.61 (0.63–4.17)
Log-additive	—	—	—	0.45 (0.21–0.93)	0.025

^aAdjusted by gender, age, smoking status, tumor stage, recurrence, and metastasis. Italicized values indicated a significant difference at the 5 % level

n number of individuals