Table 1. The embryological and PGD results for investigated couple.
| PGD FISH program | PGD NGS program | |
|---|---|---|
| Start date | January 2012 | September 2013 |
| Antral follicles count | 17 | 10 |
| Stimulation duration (d) | 9 | 10 |
| hMG total dosage (IU) | 2,025 | 2,250 |
| Number cumulus oocyte complexes | 12 | 15 |
| MII | 6 | 11 |
| 2PN | 4 | 5 |
| Number of embryos biopsied on day 3 | 3 | 3 |
| Embryos PGD results | 1: (14q D14S1419 × 2) (D15Z4 × 2) | 1: normal, 46, XX |
| 2: (14q D14S1419 × 0) (D15Z4 × 1) | 2: unbalanced, 45 (−22) | |
| 3: (14q D14S1419 × 3) (D15Z4 × 2) | 3: unbalanced, 44, (−7, −11, −17, +21) | |
| Total reads | 1 embryo: 4 | 1 embryo: 51,810 |
| 2 embryo: 1 | 2 embryo: 73,847 | |
| 3 embryo: 5 | 3 embryo: 70,246 | |
| Embryos transferred | 1 | 1 |
| 4 wk 2 d hCG level (mIU/mL) | 94 | 322,3 |
| Ongoing pregnancy | No (miscarriage in wk 10) | Healthy baby born |
Abbreviations: FISH, fluorescent in situ hybridization; hCG, human chorionic gonadotropin; hMG, human menopausal gonadotropin; MII, metaphase II; NGS, next-generation sequencing; PGD, preimplantation genetic diagnosis.