Table 5.

Meta-analysis results¹ between MESA² and HRS³ (p-values < 1×10⁻⁵) for repeated measures depressive symptom score GEE analyses

Race	CHR	SNP	Location	Coded allele	Coded allele frequency	Z-score	P-value	Direction4,5	Closest gene6 within ±50kB
African American
	1	rs10776776	114384683	T	0.55	4.73	2.30×10−6	++	(SYT6)
	1	rs1417303	235193008	T	0.59	−4.43	9.46×10−6	--	LOC440737
	2	rs4629180	101454802	A	0.83	−4.51	6.41×10−6	--	(LOC731220)
	2	rs6711630	126534599	T	0.93	4.58	4.70×10−6	++
	7	rs10249133	12514004	T	0.39	−4.47	7.67×10−6	--	(LOC100133035)
	8	rs17067630	3661853	A	0.85	4.70	2.57×10−6	++	CSMD1
	11	rs11036016	40661316	A	0.80	4.68	2.94×10−6	++	LRRC4C
	15	rs4551976	49264445	T	0.63	−4.45	8.48×10−6	--	(CYP19A1)
	16	rs365962	85267450	C	0.69	−4.53	5.83×10−6	--	(LOC101928614)
	20	rs2426733	55454729	A	0.40	−4.75	2.07×10−6	--	(RBM38)
European American
	1	rs12031875	71357685	A	0.82	4.81	1.54×10−6	++	ZRANB2-AS2
	4	rs6842756	185341452	A	0.92	4.98	6.54×10−7	++	ENPP6
	6	rs6941340	16145531	T	0.48	−4.47	7.95×10−6	--
	9	rs11794102	111772109	A	0.91	4.54	5.70×10−6	++	PALM2-AKAP2
	13	rs6492314	110267411	C	0.28	−4.75	2.00×10−6	--
	16	rs12921740	20219533	T	0.51	−4.55	5.44×10−6	--	(GP2)
	18	rs2612547	41290709	A	0.83	4.47	7.94×10−6	++	SLC14A2
All samples
	1	rs2300177	71270950	T	0.19	−4.56	5.09×10−6	? − +−−?	PTGER3
	1	rs1539418	145676734	A	0.16	−4.53	5.87×10−6	----??
	1	rs7415169	168997688	A	0.85	4.70	2.58×10−6	++++++
	2	rs6711630	126534599	T	0.93	4.58	4.70×10−6	+????+
	2	rs41379347	191577187	T	0.89	−5.22	1.81×10−7	??--??	STAT1
	4	rs6552764	185341497	A	0.86	4.64	3.41×10−6	− + ? − ++	ENPP6
	8	rs12541177	124869454	T	0.31	−4.48	7.43×10−6	------	FAM91A1
	9	rs9408311	38704682	T	0.84	4.92	8.87×10−7	++ − +++
	15	rs16975781	94245464	T	0.90	4.62	3.83×10−6	+++++−
	16	rs12921740	20219533	T	0.59	−4.70	2.61×10−6	-−− + −−	(GP2)

¹Filtered at ethnicity-specific minor allele frequency of 5 %, where the SNP was present in at least two ethnicities, linkage disequilibrium R² < 80 %, and heterogeneity p-value ≥ 0.1; ²Multi-Ethnic Study of Atherosclerosis; ³Health and Retirement Study ⁴Order corresponding to direction positions: African, European, Chinese, Hispanic American; ⁵For all samples analyses, order corresponding to direction position: MESA African American, MESA European American, MESA Chinese American, MESA Hispanic American, HRS European American, HRS African American; ⁶parentheses indicate location outside of gene