Fig 4. Prevalence of reporting of (A) randomisation, (B) blinded assessment of outcome, (C) sample size calculations, and (D) conflict of interest reporting by decile of journal impact factor in 2,671 publications describing the efficacy of interventions in animal models of eight different diseases identified in the context of systematic reviews.

Black lines indicate the median value in that decile, and grey lines indicate the 95% confidence limits derived from nonparametric median regression (S4 Data).