Table 3.
Ion Torrent hotspot sequencing data for select mixed-type tumors.
| Case ID | Gene | DNA Alteration | Protein change | Histology | Frequency (%) | Difference | Coverage | COSMIC ID | Mix Type |
|---|---|---|---|---|---|---|---|---|---|
| MX11 | PIK3CA | c.1624G>A | p.E542K | EC | 87.7 | 65.6 | 16201 | COSM760 | Endometrioid and Clear Cell |
| CCC | 22.1 | 444 | |||||||
| MX2 | CTNNB1 | c.98C>G | p.S33C | EC | 30.8 | 30.8 | 2599 | COSM5677 | |
| CCC | 0 | 2520 | |||||||
| MX12 | PTEN | c.522_523delTG | p.Y176Lfs*4 | EC | 30.2 | 5 | 1450 | N/A | |
| CCC | 25.2 | 4745 | |||||||
| TP53 | c.524G>A | p.R175H | EC | 56.3 | 36.9 | 1593 | COSM10648 | ||
| CCC | 93.2 | 2627 | |||||||
| MX3 | TP53 | c.481G>A | p.A161T | EC | 20.8 | 20.8 | 2264 | COSM10739 | |
| CCC | 0 | 4350 | |||||||
| MX27 | TP53 | c.524G>A | p.R175H | HGSC | 83.7 | 83.7 | 4846 | COSM10648 | High Grade Serous and Clear Cell |
| CCC | 0 | 4410 | |||||||
| MX21 | TP53 | c.404G>A | p.C135Y | HGSC | 33.6 | 1.4 | 9799 | COSM10801 | |
| CCC | 35 | 9808 | |||||||
| IDH1 | c.395G>A | p.R132H | HGSC | 1 | 6.1 | 3238 | COSM28746 | ||
| CCC | 7.1 | 4251 | |||||||
| MX28 | MET | c.1124A>G | p.N375S | HGSC | 46.8 | 8.7 | 2964 | COSM710 | |
| CCC | 38.1 | 3121 | |||||||
| TP53 | c.380C>T | p.S127F | HGSC | 44.1 | 5.1 | 4686 | COSM44226 | ||
| CCC | 39 | 8064 | |||||||
| MX7 | PIK3CA | c.3140A>T | p.H1047L | CCC | 50.7 | 29.5 | 1495 | COSM776 | Mucinous and Clear Cell |
| MBOT | 21.2 | 811 | |||||||
| MX8 | KRAS | c.35G>A | p.G12D | CCC | 82.9 | 60.4 | 5006 | COSM521 | |
| MC | 22.5 | 7139 | |||||||
| MX4 | KRAS | c.35G>T | p.G12V | EC | 55.6 | 7 | 6023 | COSM520 | Endometrioid and Low Grade Serous |
| LGSC | 62.6 | 6890 | |||||||
| CTNNB1 | c.94G>A | p.D32N | EC | 37 | 37 | 2836 | COSM5672 | ||
| LGSC | 3.3 | 3240 | |||||||
| MX5 | TP53 | c.528C>G | p.C176W | EC | 71.2 | 33.2 | 2108 | COSM11114 | |
| LGSC | 38 | 3285 |