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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Neuroimage. 2015 Jul 26;121:253–262. doi: 10.1016/j.neuroimage.2015.07.049

Table 4.

Kinetic parameters of [11C]TZ1964B PET brain imaging in NHPs following pharmacological pretreatment

Doses of MP-10 (mg/kg) Kinetic parameters (Striatum)
LoganREF SRTM
BPND Occ% BPND R1 k2 (min−1) Occ %
2.00 0.4231 89.23 0.6558 1.0209 0.04245 86.65
1.50 0.4234 89.17 0.5732 0.8844 0.08179 80.00
1.00 0.8980 77.14 0.9026 0.9932 0.05868 81.63
0.50 0.8214 79.09 1.3084 0.7716 0.08542 73.37
0.25 2.8957 26.26 3.8161 1.0628 0.08540 22.32
0.10 3.7678 4.06 4.0338 1.1128 0.10847 17.79
0.05 3.7307 5.01 4.0253 0.9354 0.09479 18.07