TABLE 1.
Demographic characteristics of infants with S. aureus bloodstream infection who received early adequate or inadequate empirical antibiotic therapy
| Inadequate Empirical Antibiotics N = 725 (%) |
Adequate Empirical Antibiotics N = 2614 (%) |
P-value | |
|---|---|---|---|
| Gestational age, weeks | |||
| <26 | 151 (21) | 659 (25) | <0.01 |
| 26-28 | 229 (32) | 932 (36) | |
| 29-32 | 158 (22) | 629 (24) | |
| 33-36 | 86 (12) | 220 (8) | |
| >37 | 101 (14) | 172 (7) | |
| Birth weight, g | |||
| <1000 | 324 (45) | 1383 (53) | <0.01 |
| 1000-1499 | 179 (25) | 678 (26) | |
| 1500-2499 | 97 (13) | 343 (13) | |
| 2500-3499 | 84 (12) | 157 (6) | |
| >3500 | 41 (6) | 52 (2) | |
| Age at positive blood culture, days | |||
| <7 | 123 (17) | 235 (9) | <0.01 |
| 7-14 | 220 (30) | 766 (29) | |
| 15-28 | 186 (26) | 913 (35) | |
| >28 | 196 (27) | 700 (27) | |
| Race/ethnicity | |||
| White | 328 (47) | 1241 (49) | 0.44 |
| African-American | 182 (26) | 673 (27) | |
| Hispanic | 154 (22) | 487 (19) | |
| Other | 36 (5) | 131 (5) | |
| 5-min Apgar | |||
| 0-3 | 34 (5) | 123 (5) | 0.43 |
| 4-6 | 119 (17) | 484 (19) | |
| 7-10 | 553 (78) | 1943 (76) | |
| Male | 389 (54) | 1447 (55) | 0.45 |
| Inborn | 549 (76) | 2084 (81) | <0.01 |
| Cesarean section | 488 (68) | 1897 (73) | 0.01 |
| Small for gestational age | 118 (16) | 533 (20) | 0.01 |
| Inotrope support on day of culture | 19 (3) | 220 (8) | <0.01 |
| Oxygen support on day of culture | 365 (50) | 1684 (64) | <0.01 |
| Ventilator support on day of culture | 229 (32) | 1295 (50) | <0.01 |
| Infection with methicillin-resistant S. aureus |
280 (39) | 567 (22) | <0.01 |