TABLE 3.
30-day mortality for methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) bloodstream infections by delay in therapy
| Antibiotic Administered | Day of Therapy* |
Died /Total (%) | 30-Day Mortality Adjusted Odds Ratio (95% CI) |
|---|---|---|---|
| MSSA | |||
| Vancomycin or beta-lactam | 0 | 119/1562 (8) | REFERENCE |
| Vancomycin or beta-lactam | 1 | 9/262 (3) | 0.61 (0.29, 1.29) |
| Vancomycin or beta-lactam | 2 | 1/64 (2) | N/A† |
| Vancomycin or beta-lactam | 3 | 1/12 (8) | 3.64 (0.39, 33.76) |
| Vancomycin only | 0 | 101/1341 (8) | REFERENCE |
| Vancomycin only | 1 | 5/219 (2) | 0.44 (0.17, 1.15) |
| Vancomycin only | 2 | 1/50 (2) | N/A† |
| Vancomycin only | 3 | 1/6 (17) | 9.42 (0.83, 106.51) |
| Beta-lactam only | 0 | 12/182 (7) | REFERENCE |
| Beta-lactam only | 1 | 1/29 (4) | 0.46 (0.04, 5.09) |
| Beta-lactam only | 2 | 0/10 (0) | N/A† |
| Beta-lactam only | 3 | 0/4 (0) | N/A† |
| MRSA | |||
| Vancomycin | 0 | 39/487 (8) | REFERENCE |
| Vancomycin | 1 | 13/159 (8) | 1.62 (0.76, 3.43) |
| Vancomycin | 2 | 2/40 (4) | 1.31 (0.28, 6.05) |
| Vancomycin | 3 | 2/32 (6) | 1.38 (0.29, 6.51) |
*
Number of days after first positive culture (i.e., day 0) that particular antibiotic therapy was first received.
†
Mortality odds ratios could not be generated due to either lack of infants or missing covariate data for the single infant.