Table 1.

Effect of pretransplant BM cell-mobilization on mixed chimerism levels after BM allotransplantation

Group	Number of Animals	IS	BMT (million)	BM mobilization pretreatment		Mixed Chimerism after BMT
				AMD3100*	G-CSF	30 days	p value	90 days	p value
				1	3	None	0	None	None	0.17± 0.05		0.11± 0.02
2	3	Yes	0	None	None	0.27± 0.07		0.16± 0.03
3	6	Yes	20	None	None	0.35± 0.08	0.02 (vs group1)	0.15± 0.02	0.21 (vs group1)
4	5	Yes	20	1 mg/kg, 1Hr	None	0.15± 0.05		N/A
5	5	Yes	20	5 mg/kg, 1 Hr	None	0.13± 0.04		N/A
6	8	Yes	20	10 mg/kg,1Hr	None	1.52± 0.18	0.0007 (vs group 1) 0.0001 (vs group 3) 0.3 (vs group 12)	0.18± 0.02	0.06 (vs group 1) 0.42(vs group 3) 0.005 (vs group 12)
7	6	Yes	20	10 mg/kg, 3 Hrs	None	0.25± 0.01		0.13± 0.01
8	4	Yes	20	10 mg/kg, 10 Hrs	None	0.56± 0.11		0.18± 0.02
9	5	Yes	20	10 mg/kg, 1 & 10 Hrs	None	1.49± 0.17		0.13± 0.03
10	5	Yes	20	10 mg/kg,1 Hr	Yes	1.06± 0.13		0.15± 0.04
11	4	Yes	20	None	Yes	0.45± 0.14		0.25± 0.06
12	6	Yes	50	None	None	1.28± 0.08	0.02 (vs group 13)	1.39± 0.42	0.03 (vs group 13)
13	5	Yes	100	None	None	2.47± 0.36		3.34± 0.71

BM: bone marrow; IS: immunosuppression; BMT: bone marrow transplantation; N/A: not performed;

^*hours (Hr) before BMT