Table 1.

Cost-effectiveness studies of testing strategies for Lynch Syndrome in patients with colorectal cancer.

Study	Country	Analytic Perspective	Discount Rate (per Annum) ^	Colonoscopic Surveillance Frequency	Other Preventive Strategies Modeled
Mvundura et al. [32]	USA	US healthcare system	3%	Every 2 years starting at 20 years	None
Ladabaum et al. [31] & Wang et al. [33]	USA	Third-party payer	3.5%	Every year starting at 25 years	Subtotal colectomy by mutation carriers TAH/BSO at age 40 years
Sie et al. [34]	Netherlands	Not stated	4%	Every 2 years	None
Snowsill et al. [29,35]	UK	UK National Health Service		Every 2 years	TAH/BSO at minimum age 45 years
Severin et al. [14]	Germany	German Statutory Health Insurance system	3%	Every year starting at 25 years	Aspirin prophylaxis
Barzi et al. [30]	USA	Societal	3%	Every year starting at 20 years	None

^ All studies applied the same discount rate to costs and health outcomes in future years. TAH/BSO: total abdominal hysterectomy and bilateral salpingo-oophorectomy.