Table 2. Therapeutic indices of Bp4eT and its metabolites against neoplastic cells.
| IC50 non-cancerous cells / IC50 neoplastic cells | ||||||||
|---|---|---|---|---|---|---|---|---|
| H9c2/HL-60 | 3T3/HL-60 | H9c2/MCF-7 | 3T3/MCF-7 | H9c2/HCT116 | 3T3/HCT116 | H9c2/A549 | 3T3/A549 | |
| Bp4eT | 174.7 | 436.3 | 34.9 | 87.3 | 65.5 | 163.6 | 0.9 | 2.2 |
| Bp4eA | 8.0 | 19.7 | 7.0 | 17.3 | 3.7 | 9.2 | 2.0 | 5.0 |
| E-Bp4eS | 5.9 | >6.6 | 4.2 | >4.8 | 9.3 | >10.5 | 3.6 | >4.0 |
| Z-Bp4eS | 7.4 | >21.6 | 1.7 | >5.1 | 1.0 | >3.0 | 0.6 | >1.9 |
The therapeutic indices were calculated using the following ratio, IC50 non-cancerous cells / IC50 neoplastic cells. Results are means of n ≥ 4 experiments.