Fig 2. Regional differences in the [¹⁸F]THK-5117 SUVR annual change in HCs (A) and patients with AD (B).

Patients with AD showed greater annual change in the middle and inferior temporal gyri (4.98 ± 3.92%) and in the fusiform gyrus (5.19 ± 2.01%) than did HCs. Compared to the patient with mild AD (57-year-old male, MMSE score of 22 and ADAS-cog score of 12.7 at baseline) (C), the patient with moderate AD (86-year-old female, MMSE score of 18 and ADAS-cog score of 25.3 at baseline) showed greater annual change in the parahippocampal gyrus (7.16%), fusiform gyrus (5.17%), and middle and inferior temporal gyri (8.60%).