Table 1.

Molecular markers of the endocannabinod (eCB) system in autism and related phenotypes in humans

Biological sample	Model	eCB alterations	Reference
Postmortem brain	Human	↓CB1	[121]
PBMCs	Human	↓NAPE–PLD mRNA = FAAH, CB1 mRNA ↑CB2 mRNA and protein	[107]
Saliva	Human	CB1 SNP	[116, 119]

PBMCs = peripheral blood mononuclear cells; CB¹ = type-1 cannabinoid receptor; NAPE–PLD = N-acylphosphatidyl-ethanolamine-specific phospholipase D; FAAH = fatty acid hydrolase; CB2 = type-2 cannabinoid receptor; SNP = single nucleotide polymorphism