Table 4.
In silico predictions were performed using Polyphen-2 and SIFT. Patients responsive to gentamicin treatment are indicated in gray
ND = nondetectable
*Polyphen-2 (http://genetics.bwh.harvard.edu/pph2/) predicts the possible impact of amino acid substitutions on the stability and function of human proteins using structural and comparative evolutionary considerations. Score ranges from 0 (benign) to 1 (damaging)
†SIFT (http://sift.jcvi.org/) prediction is based on the degree of conservation of amino acid residues in sequence alignments derived from closely related sequences. Score ranges from 0 (damaging) to 1 (tolerated)