Table 5.

Most plausible molecular targets of cannabidiol (CBD) warranting further investigation in specific disease stated

Disease or disease group	Most plausible molecular targets of CBD
Epilepsy	VDAC1, CaV3.x, 5-HT1A, GlyR, GPR55, adenosine modulation (ENT1)
Movement disorders	CaV3.x, 5-HT1A, VDAC1
Neurodegenerative diseases	VDAC1, FABP, GPR55, NRF2, ENT1
Pain	TRPV1, TRPA1, TRPM8
Psychosis and anxiety	5-HT1A, adenosine modulation (ENT1)
Addiction	CYP2D6, opioid receptors, ABCG2

VDAC1 = voltage-dependent anion channel 1; 5-HT = serotonin; GlyR = glycine receptor; GPR55 = G protein-coupled receptor 55; ENT1 = equilibrative nucleoside transporter 1; FABP = fatty acid binding protein; NRF2 = Nuclear factor erythroid 2-related factor 2; TRPV1 = transient receptor potential vanilloid-type 1; TRPA1 = transient receptor potential ankyrin type 1; TRPM8 = transient receptor potential subfamily M; CYP = cytochrome P