Fig. 5.
Aβ injection impairs cognitive function of 12-month-old wild-type (WT) mice but not tau knockout (KO) mice. (a–c) Mice were injected with 1 dose of human Aβ1–42 oligomer, and cognitive functions were measured by NORT (duration of sniffing novel object) (a) 1 week, (b) 3 weeks, or (c) 5 weeks after surgery. (d–f) Y-maze test for consequences of Aβ injection (d) 1 week, (e) 3 weeks, or (f) 5 weeks after surgery. n (WT, phosphate-buffered saline) = 9; n (WT, Aβ) = 10; n (tau knockout, phosphate-buffered saline) = 5; n (tau knockout, Aβ) = 8. *p < 0.05 versus sham-injected WT mice. Data are means ± SEM