Table 1. Echocardiographic parameters in SERCA2a KO and control mice 8 weeks after gene excision and 4 weeks after initiation of sustained TLR9 stimulation.
| Controls | SERCA2a KO | |||
|---|---|---|---|---|
| PBS (n = 6) | CpG B (n = 8) | PBS (n = 12) | CpG B (n = 9) | |
| LVEF (%) | 40.5 ± 12.4 | 43.7 ± 12.0 | 41.2 ± 5.0 | 49.6 ± 8.0 * |
| CO (ml/min)/ TL | 1.4 ± 0.2 | 2.2 ± 0.8 | 1.0 ± 0.3 | 1.0 ± 0.6 ## |
| SV (ml)/TL | 3.2 ± 0.1 | 4.0 ± 1.1 | 2.3 ± 0.6 ### | 1.9 ± 0.7 ## |
| IVS;d (mm)/TL | 0.05 ± 0.005 | 0.04 ± 0.009 | 0.04 ± 0.004 | 0.05± 0.006 |
| IVS;s (mm)/TL | 0.06 ± 0.009 | 0.06 ± 0.010 | 0.05 ± 0.007 | 0.06 ± 0.007 |
| LVPW;d (mm)/TL | 0.05 ± 0.010 | 0.04 ± 0.006 | 0.05 ± 0.010 | 0.04 ± 0.006 |
| LVPW;s (mm)/TL | 0.06 ± 0.014 | 0.05 ± 0.008 | 0.054 ± 0.008 | 0.06 ± 0.010 |
| LVvol;d (μL)/TL | 4.9 ± 0.8 | 4.6 ± 0.6 | 3.6 ± 0.5 | 2.7 ± 0.6 * |
| LVvol;s (μL)/TL | 3.0 ± 0.8 | 2.6 ± 0.8 | 2.1 ± 0.3 | 1.4 ± 0.4 * |
| RWT | 0.39 ± 0.038 | 0.37 ± 0.042 | 0.43± 0.064 | 0.51 ± 0.105 ## |
| Heart rate (BPM) | 467.4 ± 55.8 | 488.6 ± 54.5 | 452.5 ± 44.2 | 428.4 ± 57.6 # |
LV, Left ventricle; EF, Ejection fraction; CO, Cardiac output; SV, Stroke volume; d, diastolic; s, systolic; TL, Tibia length (mm); IVS, inter ventricular septum thickness; LVPW, LV posterior wall thickness; LVvol, LV volume; RWT, relative wall thickness (Formula: IVS;d+LVPW;d/ LVID;d); Data are expressed as the mean±SD.
*P<0.05 vs. SERCA2a KO mice.
# P<0.05
## P<0.01
### P<0.001 vs. control with same intervention.