Figure 3.

Spatial and temporal specificity of enhancers active in the developing forebrain. Developmental dynamics of the enhancer-associated histone mark H3K27ac at putative enhancers in mouse forebrain analyzed by ChIP-seq across seven stages of brain development. Most sites show temporally restricted H3K27ac marks. Each column of the heat map displays H3K27ac enrichment patterns from a collection of putative enhancers for a given developmental stage, which are arranged from constitutively active enhancers at the top to more developmental-stage-specific enhancers proceeding downward.