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. 2015 Oct 14;35(41):13868–13878. doi: 10.1523/JNEUROSCI.2602-15.2015

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Copyright © 2015 the authors 0270-6474/15/3513868-11$15.00/0

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Figure 3. — A, Left, Region-of-interest analysis showing that, for “immediate reward valuation” within the right ventral striatum, healthy comparison women (CW) had a greater response when hungry than when satiated; when satiated, remitted anorexia nervosa (RAN) had a greater response than CW. Right, Cognitive-related region-of-interest analysis for the “all decisions” analysis. Within the right middle frontal gyrus, RAN responded more strongly than CW for all trials. Error bars represent the SE for each group. *p = 0.05; **p = 0.01. B–D, Comparison of ventral limbic and dorsal cognitive circuits in CW showing hunger (B) enhances limbic and reduces cognitive activity whereas satiety (C) reverses these neural processes. However, in RAN, there is (D) reduced limbic and enhanced cognitive function whether hungry or satiated (Wierenga et al., 2015).