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. Author manuscript; available in PMC: 2015 Oct 14.
Published in final edited form as: Blood Cells Mol Dis. 2013 Oct 5;51(4):256–263. doi: 10.1016/j.bcmd.2013.08.005

Fig. 1.

Fig. 1

Three independent waves of hematopoietic generation in the developing mouse embryo. Three waves of embryonic hematopoiesis are depicted along a developmental time line. Embryonic day (E) 7.5 to 10.5 mouse embryos are shown. Arrows indicate the onset of hematopoietic cell generation (but do not necessarily indicate the later time point when this generation ceases). The first wave is thought to be derived from hemangioblasts, whereas waves 2 and 3 are derived from hemogenic endothelial cells. The most potent adult-repopulating HSCs are generated at E10.5 inthe AGM. YS = yolk sac; pSp = para-aortic splanchnopleura; AGM = aorta–gonad–mesonephros; V/U = vitelline and umbilical arteries; PL = placenta; EMP = erythro-myeloid progenitors; HSC = hematopoietic stem cell.