Fig. 1.

Brain edge regions with greater loss of brain volume in schizophrenia patients compared to controls (adjusted for sex, handedness and interscan interval, p < 0.05 family-wise error corrected across brain edge). Patients with schizophrenia showed significantly greater regional brain structural atrophy than controls in the right frontal pole, right middle and inferior frontal gyrus, bilateral central gyrus, bilateral supramarginal gyrus, bilateral temporal lobe (including superior, middle and inferior divisions), right occipital cortex inferior division, right lingual gyrus (mid-line occipital lobe) and bilateral precuneous cortex.