Table 2.

Regions in which there were voxels showing greater volume loss in schizophrenia patients compared to controls (p < 0.05, FWE corrected, adjusted for sex, handedness and interscan interval).

Regions	Group	Mean of Edge Displacement (mm)		Number of Voxels	t	p (peak)	Coordinate of p Peak Voxel (MNI152 mm)
Mean	SD	x	y	z
Right frontal pole	Schizophrenia	− 0.42	0.29	694	4.20	.004	48	52	12
Control	− 0.21	0.17
Right middle frontal gyrus	Schizophrenia	− 0.43	0.30	169	3.72	.006	56	34	18
Control	− 0.20	0.22
Right inferior frontal gyrus	Schizophrenia	− 0.43	0.23	330	3.58	.004	64	6	2
Control	− 0.25	0.17
Bilateral central gyrus	Schizophrenia	− 0.42	0.23	637	4.58	< .001	66	0	2
Control	− 0.22	0.14
Bilateral supramarginal gyrus	Schizophrenia	− 0.35	0.26	607	5.65	< .001	− 70	− 44	− 2
Control	− 0.14	0.15
Bilateral temporal lobe	Schizophrenia	− 0.29	0.18	1726	5.67	< .001	− 68	− 46	− 10
Control	− 0.11	0.10
Right occipital cortex (inferior division)	Schizophrenia	− 0.28	0.23	182	3.57	.010	60	− 70	2
Control	− 0.09	0.24
Right lingual gyrus (mid-line occipital)	Schizophrenia	− 0.04	0.08	34	6.14	.011	8	− 62	6
Control	0.05	0.07
Bilateral precuneous cortex	Schizophrenia	− 0.13	0.10	95	4.68	.026	− 4	− 58	54
Control	− 0.04	0.05

Note: For reporting purposes, brain changes (p < 0.05 family-wise error corrected across the brain edge) were parcellated into regions using the Harvard–Oxford cortical structural atlas/MNI structural atlas.