Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 14;6:226. doi: 10.3389/fphar.2015.00226

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Daniele, Di Rosa, Giallongo, La Cava, Parrinello, Romano, Conticello, Brundo, Saccone, Malaguarnera and Di Raimondo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The MM cells line (U266, SKM-M1, and MM1) express different levels of CHIT1 activity (A) and chitinase mRNA expression CHIT1 and YKL40 (B). The treatment of U266 with BO (2.5 and 5 nM) for 24 h reduce the mRNA expression of CHIT1 and YKL40 (C). Determination of resorption pits on dentin disk showed a significant reduction in the cells treated with CHIT1 siRNA, YKL40 siRNA and in the co-silencing with CHIT1 and YKL40 siRNA (DS) compared to the negative control (SS) (D). Results are expressed as the number of resorption pits. Data are expressed as mean ± SD of at least three independent experiments.*P<0.01, **P<0.001, ***P<0.0001.