Table 2.

The influence of accounting for the rs6449173 average effect on the estimated serum urate variance effect.

	N	β∗	SE	P
ARIC	5356
Mean effect		0.023	0.002	8.7 × 10-56
Unadjusted variance effect		-0.153	0.033	4.1 × 10-6
Adjusted variance effect		0.024	0.033	0.47
FHS	3282
Mean effect		0.023	0.002	2.7 × 10-38
Unadjusted variance effect		-0.192	0.042	5.8 × 10-6
Adjusted variance effect		0.063	0.043	0.14
ARIC diuretics	1196
Mean effect		0.031	0.004	2.5 × 10-12
Unadjusted variance effect		-0.117	0.073	0.11
Adjusted variance effect		0.043	0.073	0.56
CHS	2799
Mean effect		0.023	0.003	2.0 × 10-19
Unadjusted variance effect		-0.156	0.045	4.7 × 10-4
Adjusted variance effect		-0.016	0.045	0.72
CARDIA	1496
Mean effect		0.026	0.003	2.6 × 10-22
Unadjusted variance effect		-0.079	0.062	0.20
Adjusted variance effect		0.208	0.061	7.3 × 10-4
Combined	14129
Mean effect		0.024	0.00095	4.7 × 10-140
Unadjusted variance effect		-0.152	0.020	7.9 × 10-14
Adjusted variance effect		0.047	0.020	0.022

^∗Mean effect units mmol/L urate; variance effect is estimate of allelic additive effect on z².