Table 3.

Association of rs6449173 genotype with serum urate variance in sample sets stratified into men, pre-menopausal women and post-menopausal women, with adjustment for rs6449173 mean effect.

		N	Variance β∗	SE	P	r2 #
ARIC	Total	5356	0.024	0.033	0.47	0.00010
	Men	2453	-0.053	0.050	0.28	0.00047
	Pre-menopausal women	515	0.188	0.105	0.074	0.00624
	Post-menopausal women	1447	0.083	0.063	0.19	0.00119
FHS	Total	3282	0.063	0.043	0.14	0.00067
	Men	1517	-0.008	0.063	0.89	0.00001
	Pre-menopausal women	1513	0.165	0.062	7.6 × 10-3	0.00470
	Post-menopausal women	159	-0.015	0.187	0.93	0.00004
ARIC diuretics	Total	1196	0.043	0.073	0.56	0.00029
	Men	410	-0.088	0.126	0.49	0.00119
	Pre-menopausal women	90	0.430	0.271	0.12	0.02811
	Post-menopausal women	401	0.102	0.128	0.43	0.00159
CHS	Total	2799	-0.016	0.045	0.72	0.00005
	Men	1089	-0.121	0.073	0.097	0.00253
	Pre-menopausal women	0	–	–	–	–
	Post-menopausal women	1528	0.093	0.062	0.13	0.00150
CARDIA	Total	1496	0.208	0.061	7.3 × 10-4	0.00762
	Men	693	0.112	0.092	0.23	0.00211
	Pre-menopausal women	527	0.231	0.100	0.022	0.00997
	Post-menopausal women	42	0.269	0.369	0.47	0.01304
Combined∧	Total	14129	0.047	0.020	0.022	0.00037
	Men	6162	-0.038	0.031	0.22	0.00024
	Pre-menopausal women	2645	0.191	0.046	3.7 × 10-5	0.00637
	Post-menopausal women	3577	0.087	0.040	0.032	0.00129

^∗Variance effect is estimate of allelic additive effect on z².

^∧Combined by meta-analysis using a fixed effects model.

# r² values, representing the proportion of variance in variance in serum urate explained by rs6449173, were obtained by linear regression of the adjusted z² score against rs6449173 using the lm function in R, and extracting the Multiple R² value from the output summary.