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. 2015 Oct 13;59(11):7011–7017. doi: 10.1128/AAC.01315-15

TABLE 1.

Trypanocidal activity of alkaloids and digitonin alone and in combinations

Drug IC50 ± SD of the serially diluted drug alone (μM) IC50 ± SD of the drug in combination with (μM)a:
Berberine (1.87) Chelerythrine (0.07) Emetine (0.005) Homoharringtonine (0.002) Piperine (14) Vinblastine (0.04) Digitonin (0.94)
Berberine 6.85 ± 0.82 2.80 ± 0.85 6.09 ± 0.82 4.18 ± 0.35 6.05 ± 1.60 3.31 ± 0.91 2.64 ± 0.63
Chelerythrine 0.33 ± 0.006 0.30 ± 0.04 0.27 ± 0.04 0.30 ± 0.06 0.20 ± 0.04 0.25 ± 0.04 0.27 ± 0.06
Emetine 0.03 ± 0.007 0.02 ± 0.002 0.02 ± 0.001 0.01 ± 0.002 0.02 ± 0.002 0.01 ± 0.004 0.01 ± 0.001
Homoharringtonine 0.01 ± 0.0002 0.009 ± 0.002 0.009 ± 0.002 0.007 ± 0.002 0.01 ± 0.003 0.009 ± 0.001 0.009 ± 0.002
Piperine 72.40 ± 2.43 31.88 ± 2.37 57.47 ± 11.70 16.83 ± 1.94 53.31 ± 2.40 35.03 ± 1.71 55.09 ± 6.75
Vinblastine 0.21 ± 0.06 0.12 ± 0.007 0.22 ± 0.02 0.13 ± 0.02 0.22 ± 0.01 0.03 ± 0.01 0.02 ± 0.006
Digitonin 6.89 ± 0.57 4.02 ± 1.09 8.39 ± 0.55 11.47 ± 0.85 6.80 ± 0.90 7.03 ± 0.84 8.13 ± 1.01
a

A fixed concentration (indicated in parentheses) was chosen for each combination partner.